The purpose of this study was to formulate sustained release pellets formulation and to investigate release profiles by using different polymers for the coating of pellets. The Itopride hydrochloride loaded pellets were coated with different polymers (ethyl cellulose and kollicoat SR 30 D) at different coating levels. Drug release from pellets as well as physical parameters such as size distribution, bulk density and tapped density etc. were evaluated. Drug release from the pellets strongly depends on type of polymers and coating variables such as coating levels etc. The various polymers show different release mechanism. The sustained-release matrix pellets with good physical, mechanical and technological properties were obtained with a ethylcellulose polymer of coating level of 10%(w/w). A comparative kinetic study of the present pellets and commercial Ganaton OD capsules was established. The value for the similarity factor (f= 77.6) suggested that the dissolution profile of the present two sustained-release oral dosage forms are similar. The type of polymer coating strongly affects the film microstructure and thus, the release mechanism and rate from pellets coated with different polymer.