Freeze-thaw electrospun PVA-dacarbazine nanoparticles: Preparation, characterization and anticancer evaluation
International Journal of Polymeric Materials and Polymeric Biomaterials, 2020•Taylor & Francis
Dacarbazine (DTIC) is an antitumor agent that has limited clinical applications due to its
insolubility, instability and toxicity to normal cells. One possibility to achieve controlled
release is PVA-based NPs. This work presents electrospun NPs that combines PVA and
DTIC. The results showed that DTIC NPs had mean particle sizes of 458.2±113.6 nm,
suggested the presence of DTIC in an amorphous state and showed a burst in vitro drug
release followed by constant release. The cytotoxicity evaluation showed that DTIC NPs …
insolubility, instability and toxicity to normal cells. One possibility to achieve controlled
release is PVA-based NPs. This work presents electrospun NPs that combines PVA and
DTIC. The results showed that DTIC NPs had mean particle sizes of 458.2±113.6 nm,
suggested the presence of DTIC in an amorphous state and showed a burst in vitro drug
release followed by constant release. The cytotoxicity evaluation showed that DTIC NPs …
Abstract
Dacarbazine (DTIC) is an antitumor agent that has limited clinical applications due to its insolubility, instability and toxicity to normal cells. One possibility to achieve controlled release is PVA-based NPs. This work presents electrospun NPs that combines PVA and DTIC. The results showed that DTIC NPs had mean particle sizes of 458.2 ± 113.6 nm, suggested the presence of DTIC in an amorphous state and showed a burst in vitro drug release followed by constant release. The cytotoxicity evaluation showed that DTIC NPs were effective against glioblastoma cells. This study indicates that the formulated NPs improved DTIC solubility and efficacy.
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