as per the ICH guidelines. In this study the 20 mM ammonium formate and acetonitrile in the
57: 43 ratio were used as mobile phase for the analysis of valsartan. Full factorial design
was used to optimize the effect of variable factors. The responses were peak area, tailing
factor and number of theoretical plates. The quadratic effect of flow rate and wavelength
individually as well as in interaction were most significant (p< 0.0001 and p< 0.0086 …