An important question in memory development is understanding the differences between
effector CD8 T cells that die versus effector cells that survive and give rise to memory cells.
In this study, we provide a comprehensive phenotypic, functional, and genomic profiling of
terminal effectors and memory precursors. Using killer cell lectin-like receptor G1 as a
marker to distinguish these effector subsets, we found that despite their diverse cell fates,
both subsets possessed remarkably similar gene expression profiles and functioned as …

An important question in memory T cell differentiation is understanding the mechanisms that
regulate the generation of terminal effector cells that die following antigen clearance versus
effector cells that give rise to the long‐lived pool of memory CD8 T cells. Using killer cell
lectin‐like receptor G1 as a marker to effectively distinguish terminal effectors from memory
precursors, we found that despite their diverse cell fates both subsets possess remarkably
similar gene expression profiles and function as equally potent direct ex vivo killer cells, with …