Functional Characterization of Triclosan-Resistant Enoyl-acyl-carrier Protein Reductase (FabV) in Pseudomonas aeruginosa
YH Huang, JS Lin, JC Ma, HH Wang - Frontiers in Microbiology, 2016 - frontiersin.org
Pseudomonas aeruginosa is extremely resistant to triclosan. Previous studies have shown
that P. aeruginosa encodes a triclosan-resistant enoyl-acyl-carrier protein reductase (ENR),
FabV, and that deletion of fabV causes P. aeruginosa to be extremely sensitive to triclosan.
In this report, we complemented a P. aeruginosa fabV deletion strain with several triclosan-
resistant ENR encoding genes, including Vibrio cholerae fabV, Bacillus subtilis fabL and
Enterococcus faecalis fabK. All complemented strains restored triclosan resistance to the …
that P. aeruginosa encodes a triclosan-resistant enoyl-acyl-carrier protein reductase (ENR),
FabV, and that deletion of fabV causes P. aeruginosa to be extremely sensitive to triclosan.
In this report, we complemented a P. aeruginosa fabV deletion strain with several triclosan-
resistant ENR encoding genes, including Vibrio cholerae fabV, Bacillus subtilis fabL and
Enterococcus faecalis fabK. All complemented strains restored triclosan resistance to the …
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