Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 …
R Pulido, MJ Elices, MR Campanero, L Osborn… - Journal of Biological …, 1991 - ASBMB
The human integrin VLA (very late activation antigens)-4 (CD49d/CD29), the leukocyte
receptor for both the CS-1 region of plasma fibronectin (Fn) and the vascular cell surface
adhesion molecule-1 (VCAM-1), also mediates homotypic aggregation upon triggering with
specific anti-VLA-4 monoclonal antibody (mAb). Epitope mapping of this integrin on the
human B-cell line Ramos, performed with a wide panel of anti-VLA-4 mAb by both cross-
competitive cell binding and protease sensitivity assays, revealed the existence of three …
receptor for both the CS-1 region of plasma fibronectin (Fn) and the vascular cell surface
adhesion molecule-1 (VCAM-1), also mediates homotypic aggregation upon triggering with
specific anti-VLA-4 monoclonal antibody (mAb). Epitope mapping of this integrin on the
human B-cell line Ramos, performed with a wide panel of anti-VLA-4 mAb by both cross-
competitive cell binding and protease sensitivity assays, revealed the existence of three …
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