Fungal small RNAs ride in extracellular vesicles to enter plant cells through clathrin-mediated endocytosis
Small RNAs (sRNAs) of the fungal pathogen Botrytis cinerea can enter plant cells and hijack
host Argonaute protein 1 (AGO1) to silence host immunity genes. However, the mechanism
by which these fungal sRNAs are secreted and enter host cells remains unclear. Here, we
demonstrate that B. cinerea utilizes extracellular vesicles (EVs) to secrete Bc-sRNAs, which
are then internalized by plant cells through clathrin-mediated endocytosis (CME). The B.
cinerea tetraspanin protein, Punchless 1 (BcPLS1), serves as an EV biomarker and plays an …
host Argonaute protein 1 (AGO1) to silence host immunity genes. However, the mechanism
by which these fungal sRNAs are secreted and enter host cells remains unclear. Here, we
demonstrate that B. cinerea utilizes extracellular vesicles (EVs) to secrete Bc-sRNAs, which
are then internalized by plant cells through clathrin-mediated endocytosis (CME). The B.
cinerea tetraspanin protein, Punchless 1 (BcPLS1), serves as an EV biomarker and plays an …
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