… effects, similar to BET inhibitors. This study identified furopyridine derivatives 7 and 8 with
high … induced by CD28 co-stimulation leads to the discovery of a first bromodomain inhibitor …

… Several BET bromodomain inhibitors are currently under clinical devel… inhibitors is based
on the furopyridine compounds reported by GSK (Fig. 33). Majority of these furopyridines have …

… design of dual kinase–bromodomain inhibitors that possess complementary pharmacology
… (47, 48) Additionally, researchers at GSK reported the novel thienopyridinone, furopyridine …

… Pomeratnz et al. described a series of dual kinase-bromodomain inhibitors with preferential
binding … Fused 1,4-diazepines as BET bromodomain inhibitors and their preparation patent …

… through their bromodomains to regulate gene transcription. Dual-bromodomain BET inhibitors
(DbBi) that bind with similar affinities to the first (BD1) and second (BD2) bromodomains of …

… inhibitors have been reported in the literature. Researchers have described thienopyridinone,
furopyridine and … In summary, this editorial highlights the use of bromodomain inhibitors as …

… Clinical studies have shown that inhibitors of bromodomain and extra-terminal domain (BET…
bioavailable BD1-selective inhibitors. In this study, we obtained a BD1 inhibitor, a more …

… γ-carboline derivatives act as BET bromodomain inhibitor.12 Because of their importance
in … one-pot synthesis of isoquinolines, furopyridines, and thienopyridiens using Pd-catalyzed …

Imidazo[1,2‐a]pyridine is a well‐known scaffold in many marketed drugs, such as Zolpidem,
Minodronic acid, Miroprofen and DS‐1 and it also serves as a broadly applied …

… Here, we describe an intracellular NanoBRET competition assay that can be used to quantify
cellular kinetic rates of compound binding to nanoluciferase-fused bromodomain and extra-…