… We follow with a discussion of several issues to be considered in designing and executing
a clinical trial with a futility stopping rule, a case study of a clinical trial that stopped for futility, …

… futility, also referred to as a go/nogo decision, during interim analysis has become an important
feature of clinical trial … a new approach to futility stopping in clinical trial designs and the …

… clinical trial, for interim analyses (IAs). We focus on early futility decisions in randomized clinical
trials (RCTs). … The trial is stopped early for futility if this predictive probability falls below a …

… clinical trials and describes the futility index, a probabillstk basis for early termination of trials
of … Utilization of the futility index in the management of cllnkal trials of innovations can be of …

… A number of methods for addressing futility have been described … We consider futility stopping
from the point of view of … , stopping trials which should continue, and continuing trials which …

… Interim monitoring of clinical trials allows for a clinical trial to be stopped early if the final …
stopped for futility [7]. One potential disadvantage of stopping clinical trials early for futility is that …

… We aimed to see whether examining futility would stop the five ‘negative’ trials early (and
if so, what the savings could be), but not any of the others. In UKHAN, no effect was shown in …

… science of planned interim futility analyses in clinical trials that test a superiority … trials for
futility advisable and not advisable. This chapter outlines four statistical methods of interim futility …

… In this tumour, clinical trials have shown that the proportion of patients with progression-free
survival (PFS) at 3 months is 39% on active treatment regimens, and 21% for inactive …

… Clinical trials may be stopped for futility if there is little or no chance of … trial conclusions,
or event rates too low to support meaningful comparisons. An example of the last type of futility …