[引用][C] G-CSF Prevents Cardiac Remodeling after Myocardial Infarction by Activating Jak/STAT in Cardiomyocytes (Vascular Regeneration (M), The 69th Annual …
H Mutsuo, Q Yingjie, M Tohru, T Haruhiro… - … journal: official journal …, 2005 - cir.nii.ac.jp
… Department of Cardiovascular Science and Medicine … Department of Cardiovascular
Science and Medicine … Department of Cardiovascular Science and Medicine …
Science and Medicine … Department of Cardiovascular Science and Medicine …
G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes
M Harada, Y Qin, H Takano, T Minamino, Y Zou… - Nature medicine, 2005 - nature.com
Granulocyte colony-stimulating factor (G-CSF) was reported to induce myocardial
regeneration by promoting mobilization of bone marrow stem cells to the injured heart after
myocardial infarction, but the precise mechanisms of the beneficial effects of G-CSF are not
fully understood. Here we show that G-CSF acts directly on cardiomyocytes and promotes
their survival after myocardial infarction. G-CSF receptor was expressed on cardiomyocytes
and G-CSF activated the Jak/Stat pathway in cardiomyocytes. The G-CSF treatment did not …
regeneration by promoting mobilization of bone marrow stem cells to the injured heart after
myocardial infarction, but the precise mechanisms of the beneficial effects of G-CSF are not
fully understood. Here we show that G-CSF acts directly on cardiomyocytes and promotes
their survival after myocardial infarction. G-CSF receptor was expressed on cardiomyocytes
and G-CSF activated the Jak/Stat pathway in cardiomyocytes. The G-CSF treatment did not …