GPRC6A mediates the non-genomic effects of steroids
The identity of the putative G-protein coupled receptor (GPCR) that mediates the non-
genomic effects of androgens is unknown. We present in vitro and in vivo evidence that the
orphan GPRC6A receptor, a widely expressed calcium and amino acid sensing GPCR,
transduces the non-genomic effects of testosterone and other steroids. Overexpression of
GPRC6A imparts the ability of extracellular testosterone to illicit a rapid, non-genomic
signaling response in HEK-293 cells lacking the androgen receptor. Conversely …
genomic effects of androgens is unknown. We present in vitro and in vivo evidence that the
orphan GPRC6A receptor, a widely expressed calcium and amino acid sensing GPCR,
transduces the non-genomic effects of testosterone and other steroids. Overexpression of
GPRC6A imparts the ability of extracellular testosterone to illicit a rapid, non-genomic
signaling response in HEK-293 cells lacking the androgen receptor. Conversely …
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