… Under stress, the overexpression of GRP78 on the cell membrane mediates the vast … viral)
to enter the cell and to start different pathways leading to pathogenesis. Additionally, GRP78 is …

… GRP78 expression in stressed cells, and sensitized cells to apoptosis [39]. Other reports
demonstrate that GRP78 … ER stress resistant lung cancer cells displayed GRP78 and phospho-…

… The discovery of GRP78 expression on the cell surface of cancer cells further leads to the
development of new therapeutic approaches targeted against cancer, in particular, hypoxic …

… Prior to testing its involvement in stress-induced autophagy, we examined the consequence
of GRP78 depletion in human cells. To achieve this, GRP78 was knocked down by …

… expression was examined as a combined measure of percentage of overall immunoreactive
tumor cells and intensity (Grp78 status), Grp78 expression remained significantly elevated …

… This sort of capacity can be enhanced by stresses under which GRP78 is induced rapidly. …
in non-GRP78 inducing mutant cells or in GRP78 knockdown cells. However, the level of …

… when GRP78 is knockdown in non-stressed mammalian cells, confirming that GRP78 is a
… Analogous to its suppressing activity of the UPR, GRP78 also acts as a potent suppressor of …

… cell membrane expression of GRP78. We show that GRP78 binding peptide motifs target
tumor cells … peptides composed of GRP78 binding motifs fused to a programmed cell death-…

… cell death inhibition by GRP78 involves inhibition of caspase activation. Our studies indicate
that treatment of cells with ER stress inducers causes GRP78 … GRP78 inhibits cytochrome c-…

… unique GRP78 cell surface topography, which appears to be compartmentalized to respond
… GRP78 through an ER stress response element (ERSE) found in the promoter region of the …