Gastrointestinal and metabolic function in the MPTP-treated macaque model of Parkinson's disease
A Delamarre, C MacSweeney, R Suzuki, AJH Brown… - Heliyon, 2020 - cell.com
Heliyon, 2020•cell.com
Background Gastrointestinal (GI) and metabolic function are frequently altered in
Parkinson's disease (PD). Although enteric nervous system anatomopathological alterations
have previously been reported in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)
monkey model of PD, the resulting gastric emptying and intestinal permeability functional
parameters are unknown. The current exploratory study was, thus, designed to investigate
these GI functional factors and insulin resistance in the MPTP-treated monkey. Methods …
Parkinson's disease (PD). Although enteric nervous system anatomopathological alterations
have previously been reported in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)
monkey model of PD, the resulting gastric emptying and intestinal permeability functional
parameters are unknown. The current exploratory study was, thus, designed to investigate
these GI functional factors and insulin resistance in the MPTP-treated monkey. Methods …
Background
Gastrointestinal (GI) and metabolic function are frequently altered in Parkinson's disease (PD). Although enteric nervous system anatomopathological alterations have previously been reported in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkey model of PD, the resulting gastric emptying and intestinal permeability functional parameters are unknown. The current exploratory study was, thus, designed to investigate these GI functional factors and insulin resistance in the MPTP-treated monkey.
Methods
Eight rhesus macaque monkeys (4 controls and 4 MPTP-treated) received the oral acetaminophen absorption test to measure gastric emptying, the oral FITC-dextran absorption test to investigate intestinal permeability, and the intravenous glucose tolerance test to assess insulin resistance. Constipation was evaluated using the Bristol stool scale.
Results
None of the tests, acetaminophen absorption, FITC-dextran absorption or glucose tolerance, showed a difference between control and MPTP-treated monkeys. MPTP-treated monkeys did present signs of transit acceleration.
Conclusion
While the MPTP monkey model reliably displays motor and certain non-motor symptoms of PD, the current study did not demonstrate the GI symptoms associated with PD.
cell.com
以上显示的是最相近的搜索结果。 查看全部搜索结果