Gender differences in CNS autoimmunity induced by mimicry epitope for PLP 139–151 in SJL mice

C Massilamany, S Thulasingam, D Steffen… - Journal of …, 2011 - Elsevier
Development of multiple sclerosis (MS) is more prevalent in females than in males, but the
underlying mechanisms are not clear. Microbial infections have been suspected as triggers
of MS and it is not known whether gender differences in reactivity to environmental antigens
contribute to the disease pathogenesis. We demonstrated that ACA 83–95, a mimicry
epitope from Acanthamoeba castellanii for proteolipid protein (PLP) 139–151, induces
clinical signs of encephalomyelitis in both male and female SJL mice. Conversely ACA 83 …
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