… a gene therapy Phase I clinical trial has overshadowed some recent successes in gene therapy
… The next phase of gene therapy will be focused on targeted and regulated expression of …

… gene expression in other gene therapy trials. Are there comparable changes in CFTR function
from pharmacological trials … What should we expect from sufficient CFTR gene expression …

… 1999 during a gene therapy trial at the Universi ty of Pennsylvania. Gelsinger's death was
the first to be definitively linked to a gene therapy trial. Would Mohr's be another? The trial was …

… gene therapies using viral vectors to insert genes into human cells. In fact gene therapy, long
… months before clinical centers around the country will begin their own trials of gene transfer …

… have been reports of more significant complications in other gene therapy applications. In
an unrelated gene therapy trial using an adenoviral vector to treat ornithine transcarbamylase …

Cystic fibrosis (CF) has long been seen as a candidate for treatment by gene therapy.
Reasons for this include: the genetics of CF are simple; it is an autosomal recessive disorder …

… In our phase I trial of E1A gene therapy, delivery of the E1A gene into either the thoracic or
the peritoneal cavity by means of DC-Chol cationic liposomes led to successful transfection of …

… of genetic origin that carries the additional challenges of variable penetration and slow
disease progression. Registrational trials of augmentation therapy … therapy in many countries. …

… for VEGF as a therapeutic agent. Embryonic lethality in VEGF gene deletions occurs for a …
administration to local protein delivery or gene therapy approaches. Finally, recent reports …

… In this review, we focus on viralvectors and highlight some examples of their use in clinical
trials. Acomplete, constantly updated list of human gene therapy trials in the UnitedStates is …