… , there is also greatreason to be optimistic about the prospects for successful gene therapyin
… of pulmonary gene transfer. Potentialindications for gene therapy, vectors, barriers to gene …

… pulmonary disease with an underlying single gene defect and a target for gene therapy. It is
… 1 -antitrypsin in patients with emphysema affects the course of the disease. Most attempts at …

… All gene therapy strategies are directed toward treating a specific patient and, thus, are …
In regard to lung disease, gene therapy can be conceptualized as the use of genetic …

… implementation of gene therapy for pulmonary diseases, as well … gene transfer and
consequently, therapeutic benefit. Our discussion extends beyond the relative simplicity of diseases …

… of the presently available gene therapy approaches for PH. We … gene transfer methods
for pulmonary vascular cells in vitro and describe some more recent developments for gene …

… of new gene addition and gene … in gene therapy for cystic fibrosis, alpha-1 antitrypsin
deficiency, and surfactant protein deficiencies. We will explore the different gene addition and gene …

… further enhanced by transduction with candidate therapeutic genes prior to delivery, as …
gene therapy approach for pulmonary hypertension will ultimately be as dependant on the gene …

… regarding the CF gene, its protein product and the mutational basis of disease. This …
development of gene therapy for the treatment of CF pulmonary disease. Delivery of the CF gene to …

… , and treatment of pulmonary disease in humans. Another … of genetic factors to pathogenesis
of pulmonary diseases are … on Genetic Strategies for Heart, Lung, and Blood Diseases (1…

… Perhaps this need could be addressed by gene therapies, … Despite the potential benefits of
gene therapy, no one has … the use of gene therapies to treat pulmonary fibrosis in animals, as …