General procedure for the synthesis of dinucleoside polyphosphates
S Mohamady, SD Taylor - The Journal of Organic Chemistry, 2011 - ACS Publications
S Mohamady, SD Taylor
The Journal of Organic Chemistry, 2011•ACS PublicationsDinucleoside 5′, 5′-polyphosphates (N (p) n N) play important roles in biological
processes and have been developed into drugs. However, their synthesis still remains a
challenge. Here we report a rapid and general approach to the synthesis of dinucleoside
5′, 5′-polyphosphates by coupling highly reactive nucleoside 5′-monophosphate-N-
methylimidazolium salts donors with nucleoside 5′-mono-,-di-, and-triphosphate acceptors.
processes and have been developed into drugs. However, their synthesis still remains a
challenge. Here we report a rapid and general approach to the synthesis of dinucleoside
5′, 5′-polyphosphates by coupling highly reactive nucleoside 5′-monophosphate-N-
methylimidazolium salts donors with nucleoside 5′-mono-,-di-, and-triphosphate acceptors.
Dinucleoside 5′,5′-polyphosphates (N(p)nN) play important roles in biological processes and have been developed into drugs. However, their synthesis still remains a challenge. Here we report a rapid and general approach to the synthesis of dinucleoside 5′,5′-polyphosphates by coupling highly reactive nucleoside 5′-monophosphate-N-methylimidazolium salts donors with nucleoside 5′-mono-, -di-, and -triphosphate acceptors.
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