In the last two decades, seismic fragility analysis for RC frame buildings has become critical in evaluating structure risk and safety margin due to lateral loads. In the study, the four-storey RC frame building is designed per the latest IS 1893 for seismic zone-V. Multiple fragility analysis methodologies are compared using nonlinear static pushover analysis and incremental dynamic analysis (IDA). The fragility curve for the capacity-spectrum method (CSM) was calculated using spectral displacement (S_d) as per ATC-40 instructions, and an uncertainty factor was calculated using the approximate methodology of normal (continuous) to the binomial (discrete) distribution. Traditional IDA, multiple stripe analysis, and truncated IDA curve-fitting approach produce fragility curves from IDA results. Traditional IDA results are more accurate than the others based on the coefficient of variation when examining the fragility curves for selected RC frame buildings in Surat City.