[HTML][HTML] Generation of a human induced pluripotent stem cell line from a familial Alzheimer's disease PSEN1 T119I patient

L Isaja, MS Rodríguez-Varela, M Marazita, S Mucci… - Stem Cell Research, 2021 - Elsevier
L Isaja, MS Rodríguez-Varela, M Marazita, S Mucci, T Itzcovich, P Chrem-Méndez…
Stem Cell Research, 2021Elsevier
Human induced pluripotent stem cells (hiPSC) line FLENIi001-A was reprogrammed from
dermal fibroblasts using the lentiviral-hSTEMCCA-loxP vector. Fibroblasts were obtained
from a skin biopsy of a 72-year-old Caucasian male familial Alzheimer's disease patient
carrying the T119I mutation in the PSEN1 gene. PSEN1 genotype was maintained and
stemness and pluripotency confirmed in the FLENIi001-A hiPSC line.
Abstract
Human induced pluripotent stem cells (hiPSC) line FLENIi001-A was reprogrammed from dermal fibroblasts using the lentiviral-hSTEMCCA-loxP vector. Fibroblasts were obtained from a skin biopsy of a 72-year-old Caucasian male familial Alzheimer's disease patient carrying the T119I mutation in the PSEN1 gene. PSEN1 genotype was maintained and stemness and pluripotency confirmed in the FLENIi001-A hiPSC line.
Elsevier
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