Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells

Y Kondo, T Toyoda, R Ito, M Funato, Y Hosokawa… - Diabetologia, 2017 - Springer
cells generated from human induced pluripotent stem cells (… and PDX1 + pancreatic progenitor
cells were induced at a high … a small molecule, SCG, that improves INS + cell generation

[HTML][HTML] Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells

Y Kunisada, N Tsubooka-Yamazoe, M Shoji… - Stem cell research, 2012 - Elsevier
… for generating insulin-producing cells from hiPS cells. Combined treatment with … endocrine
progenitor cells seemed to be inadequate, we screened for small molecules that induced the …

[HTML][HTML] Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells

A Kimura, T Toyoda, Y Nishi, M Nasu, A Ohta… - Stem cell …, 2017 - Elsevier
use of small molecules for PPC proliferation may aid in generating the large numbers of cells
… P/S and factors known to induce endocrine differentiation including 10 μM Alk 5 inhibitor II (…

A small molecule that directs differentiation of human ESCs into the pancreatic lineage

S Chen, M Borowiak, JL Fox, R Maehr… - Nature chemical …, 2009 - nature.com
human ESC differentiation and demonstrates the generation … for hESCs and induced
pluripotent stem cells, thus making it … endocrine progenitor cell or a more fully differentiated cell. …

[HTML][HTML] Conversion of human gastric epithelial cells to multipotent endodermal progenitors using defined small molecules

Y Wang, J Qin, S Wang, W Zhang, J Duan, J Zhang… - Cell Stem Cell, 2016 - cell.com
… derivation of human induced endodermal progenitor cells (… pancreatic endocrine cells, and
intestinal epithelial cells when … cell sources for generation of EndoSCs/EndoPCs by small

Recent developments in β-cell differentiation of pluripotent stem cells induced by small and large molecules

SS Kumar, AA Alarfaj, MA Munusamy… - … Journal of Molecular …, 2014 - mdpi.com
… Several small molecules, proteins, and growth factors … human pluripotent stem cells (hESCs
and hiPSCs) and … progenitor cells or cadaveric islets for the clinical treatment of diabetes. …

Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods

T Araoka, S Mae, Y Kurose, M Uesugi, A Ohta… - PloS one, 2014 - journals.plos.org
… mRNA from neural progenitor cells, induced from hiPSCs by SFEBq culture [38], was used
as a … Therefore, we reasoned that the generation of IM cells using the small molecule method …

Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules

F Tasnim, D Phan, YC Toh, H Yu - Biomaterials, 2015 - Elsevier
generation of DEs from hESCs [18], [31]. Therefore, to induce differentiation of hESCs into
DE using small molecules, … In the final step of the protocol, hepatic progenitor cells could be …

A small molecule K-3 promotes PDX1 expression and potentiates the differentiation of pluripotent stem cells into insulin-producing pancreatic β cells

T Yano, Y Shimaya, T Enomoto, T Kiho, S Komoriya… - Stem Cells, 2024 - academic.oup.com
… β-like cells derived from human pluripotent stem cells (PSCs) … β cell differentiation during
endocrine progenitor cell stage [30… generating functional insulinproducing cells from pluripotent

Small molecules and small molecule drugs in regenerative medicine

B Lu, A Atala - Drug discovery today, 2014 - Elsevier
… , human pluripotent stem cells {hPSCs [embryonic stem cells … several cord blood progenitor
cell products for cell therapy; for … expedite the process of hiPSC generation. For example, the …