Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells
DJ Smith, S Liu, S Ji, B Li… - Proceedings of the …, 2015 - National Acad Sciences
Invariant natural killer T (iNKT) cells comprise a small population of αβ T lymphocytes. They
bridge the innate and adaptive immune systems and mediate strong and rapid responses to
many diseases, including cancer, infections, allergies, and autoimmunity. However, the
study of iNKT cell biology and the therapeutic applications of these cells are greatly limited
by their small numbers in vivo (∼ 0.01–1% in mouse and human blood). Here, we report a
new method to generate large numbers of iNKT cells in mice through T-cell receptor (TCR) …
bridge the innate and adaptive immune systems and mediate strong and rapid responses to
many diseases, including cancer, infections, allergies, and autoimmunity. However, the
study of iNKT cell biology and the therapeutic applications of these cells are greatly limited
by their small numbers in vivo (∼ 0.01–1% in mouse and human blood). Here, we report a
new method to generate large numbers of iNKT cells in mice through T-cell receptor (TCR) …
199. Genetic Engineering of Hematopoietic Stem Cells to Generate Invariant Natural Killer T Cells
DJ Smith - Molecular Therapy, 2016 - cell.com
Invariant natural killer T (iNKT) cells comprise a small population of αβ T lymphocytes. They
bridge the innate and adaptive immune systems and mediate strong and rapid responses to
many diseases, including cancer, infections, allergies, and autoimmunity. However, the
study of iNKT cell biology and the therapeutic applications of these cells are greatly limited
by their small numbers in vivo (0.01-1% in mouse and human blood). Here, we report a new
method to generate large numbers of iNKT cells in mice through T-cell receptor (TCR) gene …
bridge the innate and adaptive immune systems and mediate strong and rapid responses to
many diseases, including cancer, infections, allergies, and autoimmunity. However, the
study of iNKT cell biology and the therapeutic applications of these cells are greatly limited
by their small numbers in vivo (0.01-1% in mouse and human blood). Here, we report a new
method to generate large numbers of iNKT cells in mice through T-cell receptor (TCR) gene …
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