Results This review summarizes associations of 6 binary phenotypes and 17 quantitative
traits with genetic markers in 26 genes. Of the 47 genetic markers, studied most were related
to cardio metabolic risk factors. Results of heritability and linkage analysis were also
collected and the highest heritability was found to be related to HDL-C (0.5). Conclusion
Considering the opportunity provided by large-scale cohort studies to investigate molecular
effects of genetic variants on causality and different omics' data, genetic studies conducted …

ABSTRACT Context Tehran Lipid and Glucose Study [TLGS], a longitudinal family based
cohort study, is the oldest and largest longitudinal family based study in Iran, aimed at
investigating effects of environmental, social and biological factors on the health of
Tehranians over time. Considering the importance of genetic studies in this aspect, here we
present a summary of the important genetic findings, and the potentiality of their
contributions to future related projects