… Although all characterized by iron excess, genetic iron overload disorders include pathological
conditions with different phenotypes, clinical expressivity and severity. The most frequent …

… the most common genetic iron overload disorder, can also … iron overload in HH are related
to mutations of certain genes involved in iron metabolism that causes increased intestinal iron …

… iron content or liver biopsy (especially if liver disease is a cause … iron overload) should be
used as appropriate. A secondary cause for iron overload should be considered if HFE genetic …

… This review is focused on those genetic defects causing systemic iron overload. Local … Most
of the genes causing systemic iron overload disorders codify for proteins involved in hepcidin …

… of a number of new genes and proteins in various iron overload disorders in animal models
and in humans. Early treatment of HH associated iron overload prevents end-organ damage, …

… hereditary hemochromatosis as a genetically heterogenous endocrine disease of iron …
due to brain iron overload, which is unique among all inherited disorders of iron overload. The …

… elucidated a genetic basis for the rare pediatric forms. For the purpose of this article, iron
overload disorders have been subclassified as hemochromatosis disorders (iron deposition in …

… of the appropriate use of genetic testing are encouraged. The … therapeutic options for patients
with iron overload disorders. … of a genetic mutation which predisposes to iron overload (ii) …

… of iron absorption, the regulation of hepatic iron transport and … genes and proteins in various
iron overload disorders in animal models and in humans. Clinical disorders of iron overload …

… report a new family with autosomal genetic iron overload due to a novel ferroportin mutation…
iron overload, while other families show a typical genetic reticuloendothelial iron overload. …