Genetic overlap between Alzheimer's disease and bipolar disorder implicates the MARK2 and VAC14 genes
OK Drange, OB Smeland, AA Shadrin… - Frontiers in …, 2019 - frontiersin.org
Background: Alzheimer's disease (AD) and bipolar disorder (BIP) are complex traits
influenced by numerous common genetic variants, most of which remain to be detected.
Clinical and epidemiological evidence suggest that AD and BIP are related. However, it is
not established if this relation is of genetic origin. Here, we applied statistical methods based
on the conditional false discovery rate (FDR) framework to detect genetic overlap between
AD and BIP and utilized this overlap to increase the power to identify common genetic …
influenced by numerous common genetic variants, most of which remain to be detected.
Clinical and epidemiological evidence suggest that AD and BIP are related. However, it is
not established if this relation is of genetic origin. Here, we applied statistical methods based
on the conditional false discovery rate (FDR) framework to detect genetic overlap between
AD and BIP and utilized this overlap to increase the power to identify common genetic …
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