ContextTen years after BRCA1 and BRCA2 were first identified as major breast cancer
susceptibility genes, the spectrum of mutations and modifiers of risk among many ethnic
minorities remain undefined. ObjectivesTo characterize the clinical predictors, spectrum, and
frequency of BRCA1 and BRCA2 mutations in an ethnically diverse high-risk clinic
population and to evaluate the performance of the BRCAPRO statistical model in predicting
the likelihood of a mutation. Design, Setting, and ParticipantsComparative analysis of …

2–6 Genetic Testing in an Ethnically Diverse Cohort of High-Risk Women: A Comparative
Analysis of BRCA1 and BRCA2 Mutations in American Families of European and African
Ancestry … 2–6 Genetic Testing in an Ethnically Diverse Cohort of High-Risk Women: A
Comparative Analysis of BRCA1 and BRCA2 Mutations in American Families of European
and African Ancestry …