Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization: a Mendelian randomisation study with data from 60 …
Background: Epidemiological studies observed gender differences in COVID-19 outcomes,
however, whether sex hormone plays a causal in COVID-19 risk remains unclear. This study
aimed to examine associations of sex hormone, sex hormones-binding globulin (SHBG),
insulin-like growth factor-1 (IGF-1), and COVID-19 risk. Methods: Two-sample Mendelian
randomization (TSMR) study was performed to explore the causal associations between
testosterone, estrogen, SHBG, IGF-1, and the risk of COVID-19 (susceptibility …
however, whether sex hormone plays a causal in COVID-19 risk remains unclear. This study
aimed to examine associations of sex hormone, sex hormones-binding globulin (SHBG),
insulin-like growth factor-1 (IGF-1), and COVID-19 risk. Methods: Two-sample Mendelian
randomization (TSMR) study was performed to explore the causal associations between
testosterone, estrogen, SHBG, IGF-1, and the risk of COVID-19 (susceptibility …
[PDF][PDF] Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization
X Li, Y Zhou, S Yuan, X Zhou, L Wang, J Sun, L Yu… - pure.ed.ac.uk
Background: Epidemiological studies observed gender differences in COVID-19 30
outcomes, however, whether sex hormone plays a causal in COVID-19 risk remains 31
unclear. This study aimed to examine associations of sex hormone, sex hormones-binding
32 globulin (SHBG), insulin-like growth factor-1 (IGF-1) and COVID-19 risk. 33 Methods: Two-
sample Mendelian randomization (TSMR) study was performed to explore 34 the causal
associations between testosterone, estrogen, SHBG, IGF-1and the risk of 35
outcomes, however, whether sex hormone plays a causal in COVID-19 risk remains 31
unclear. This study aimed to examine associations of sex hormone, sex hormones-binding
32 globulin (SHBG), insulin-like growth factor-1 (IGF-1) and COVID-19 risk. 33 Methods: Two-
sample Mendelian randomization (TSMR) study was performed to explore 34 the causal
associations between testosterone, estrogen, SHBG, IGF-1and the risk of 35
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