Genetics of brain age suggest an overlap with common brain disorders

…, Pediatric Imaging, Neurocognition and Genetics Study… - BioRxiv, 2018 - biorxiv.org
… gaps on GWAS summary statistics from each of the disorders. Notably, our results indicate
genetic overlap between brain age gap and brain disorders. Figure 5b provides exemplary …

Common brain disorders are associated with heritable patterns of apparent aging of the brain

T Kaufmann, D van der Meer, NT Doan… - Nature …, 2019 - nature.com
… apparent brain aging in several brain disorders and reveal genetic … the overlap between the
genetic underpinnings of brain ageoverlapping 20 , these results suggest shared molecular …

Analysis of shared heritability in common disorders of the brain

…, LA Farrer, LL Barnes, TG Beach, FY Demirci, E Head… - Science, 2018 - science.org
… of overlap for genetic risk factors of 25 common brain disorders. … common genetic risk sharing
among neurological disorders … , which suggests that their common variant genetic risk may …

[HTML][HTML] Analysis of shared heritability in common disorders of the brain

Brainstorm Consortium - Science (New York, NY), 2018 - ncbi.nlm.nih.gov
… of overlap for genetic risk factors of 25 common brain disorders. … common genetic risk sharing
among neurological disorders … , which suggests that their common variant genetic risk may …

Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders: evidence through univariate and multivariate mega-analysis …

N Opel, A Thalamuthu, Y Milaneschi, D Grotegerd… - Molecular …, 2021 - nature.com
… Our findings suggest a neurobiological interaction between … have reported overlapping
brain structural abnormalities in … Similar to previous reports of accurate individual brain age

Brain age prediction using deep learning uncovers associated sequence variants

BA Jónsson, G Bjornsdottir, TE Thorgeirsson… - Nature …, 2019 - nature.com
overlap with brain disorders such as schizophrenia, bipolar … and some neurological
disorders suggests that current … by deCODE genetics to study the cognitive and neurological

Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages

ML Chow, T Pramparo, ME Winn, CC Barnes… - … genetics, 2012 - journals.plos.org
… functioning in this disorder. We found abnormalities in genetic pathways governing cell …
We additionally annotated all 102 genes using DAVID and identified overlapping sets of 12, …

A common brain network links development, aging, and vulnerability to disease

G Douaud, AR Groves, CK Tamnes… - Proceedings of the …, 2014 - National Acad Sciences
suggest that the common spatial pattern of abnormalities … to relate development and
aging at genetic, molecular, or … to quantify the overlap between the spatial map of the age-related …

Analysis of shared heritability in common disorders of the brain

L Ligthart, JJ Hottenga, B Penninx, D Boomsma… - Science, 2018 - research.vu.nl
overlap for genetic risk factors of 25 common brain disorders. … common genetic risk sharing
among neurological disorders or … between age of disorder onset and heritability, suggesting

Genetic variants associated with longitudinal changes in brain structure across the lifespan

RM Brouwer, M Klein, KL Grasby, HG Schnack… - Nature …, 2022 - nature.com
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