Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial
infarction primarily affecting women. It is not known to what extent SCAD is genetically
distinct from other cardiovascular diseases, including atherosclerotic coronary artery
disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases
and 9,292 controls) identifying 16 risk loci for SCAD. Integrative functional annotations
prioritized genes that are likely to be regulated in vascular smooth muscle cells and artery …

Spontaneous coronary artery dissection (SCAD) is an understudied cause of acute
myocardial infarction primarily affecting women. It is not known to what extent SCAD is
genetically distinct from other cardiovascular diseases, including atherosclerotic coronary
artery disease (CAD). Through a meta-analysis of genome-wide association studies
including 1917 cases and 9292 controls of European ancestry, we identified 17 risk loci,
including 12 new, with odds ratios ranging from 2.04 (95% CI 1.77-2.35) on chr21 to 1.25 …