Obesity is a risk factor for a wide variety of health problems. In a genome-wide association
study (GWAS) of body mass index (BMI) in Japanese people (n= 173,430), we found 85 loci
significantly associated with obesity (P< 5.0× 10− 8), of which 51 were previously unknown.
We conducted trans-ancestral meta-analyses by integrating these results with the results
from a GWAS of Europeans and identified 61 additional new loci. In total, this study identifies
112 novel loci, doubling the number of previously known BMI-associated loci. By annotating …

Obesity is a risk factor for a wide variety of health problems. By carrying out a genome-wide
46 association study (GWAS) of body mass index (BMI) in Japanese (n= 173,430), we found
47 85 loci significantly associated (P< 5.0× 10-8), of which 51 were novel. We conducted 48
trans-ancestral meta-analyses by integrating these results with the results from a GWAS of
49 Europeans, and revealed 61 additional new loci. In total, this study identifies 112 novel
loci 50 which double the known BMI loci. By annotating associated variants with cell-type …