Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
Objective Alcohol-related pancreatitis is associated with a disproportionately large number
of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility
to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for
alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-
wide association study and functional characterisation of a new pancreatitis locus. Design
1959 European alcoholic CP patients and population-based controls from the KORA, LIFE …
of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility
to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for
alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-
wide association study and functional characterisation of a new pancreatitis locus. Design
1959 European alcoholic CP patients and population-based controls from the KORA, LIFE …
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
H Kirsten, J Rosendahl, K Seltsam, C Zimmer, S Beer… - 2018 - publica.fraunhofer.de
Objective: Alcohol-related pancreatitis is associated with a disproportionately large number
of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility
to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for
alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-
wide association study and functional characterisation of a new pancreatitis locus. Design:
1959 European alcoholic CP patients and population-based controls from the KORA, LIFE …
of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility
to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for
alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-
wide association study and functional characterisation of a new pancreatitis locus. Design:
1959 European alcoholic CP patients and population-based controls from the KORA, LIFE …
以上显示的是最相近的搜索结果。 查看全部搜索结果