The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal
conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-
analysis of genome-wide association studies for PR interval from seven population-based
European studies in the CHARGE Consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam
Study, and SardiNIA (N= 28,517). We identified nine loci associated with PR interval at P<
5× 10− 8. At the 3p22. 2 locus, we observed two independent associations in voltage-gated …

Objective PR interval (PR) is a heritable electrocardiographic measure of atrial and
atrioventricular nodal conduction. Changes in PR duration may be associated with atrial
fibrillation, heart failure and all-cause mortality. Hispanic/Latino populations have high
burdens of cardiovascular morbidity and mortality, are highly admixed and represent
exceptional opportunities for novel locus identification. However, they remain chronically
understudied. We present the first genome-wide association study (GWAS) of PR in 14 756 …