Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
MK Bakker, RAA van der Spek, W van Rheenen… - Nature …, 2020 - nature.com
Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of
stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we
performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882
controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are
new. We reveal a polygenic architecture and explain over half of the disease heritability. We
show a high genetic correlation between ruptured and unruptured intracranial aneurysms …
stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we
performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882
controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are
new. We reveal a polygenic architecture and explain over half of the disease heritability. We
show a high genetic correlation between ruptured and unruptured intracranial aneurysms …
[引用][C] Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors (vol 52, pg 1303, 2020): Genome …
HAI Stroke… - Nature …, 2021 - Nature Publishing Group
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