Genome-wide transcriptome analysis identifies alternative splicing regulatory network and key splicing factors in mouse and human psoriasis
Psoriasis is a chronic inflammatory disease that affects the skin, nails, and joints. For
understanding the mechanism of psoriasis, though, alternative splicing analysis has
received relatively little attention in the field. Here, we developed and applied several
computational analysis methods to study psoriasis. Using psoriasis mouse and human
datasets, our differential alternative splicing analyses detected hundreds of differential
alternative splicing changes. Our analysis of conservation revealed many exon-skipping …
understanding the mechanism of psoriasis, though, alternative splicing analysis has
received relatively little attention in the field. Here, we developed and applied several
computational analysis methods to study psoriasis. Using psoriasis mouse and human
datasets, our differential alternative splicing analyses detected hundreds of differential
alternative splicing changes. Our analysis of conservation revealed many exon-skipping …
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