Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study,
we describe results of DNAm quantitative trait locus (mQTL) analyses on 32,851
participants, identifying genetic variants associated with DNAm at 420,509 DNAm sites in
blood. We present a database of> 270,000 independent mQTLs, of which 8.5% comprise
long-range (trans) associations. Identified mQTL associations explain 15–17% of the …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. Here we describe
results of DNA methylation-quantitative trait loci (mQTL) analyses on 32,851 participants,
identifying genetic variants associated with DNAm at 420,509 DNAm sites in blood. We
present a database of> 270,000 independent mQTL of which 8.5% comprise long-range
(trans) associations. Identified mQTL associations explain 15-17% of the additive genetic …