Genomic variants associated with resistance to high fat diet induced obesity in a primate model

RA Harris, CE Alcott, EL Sullivan, D Takahashi… - Scientific Reports, 2016 - nature.com
… we have consistently observed that a 36% fat diet leads to obesity in the majority, but not all,
genomic loci rendering resistance to obesity despite chronic consumption of a high fat diet

[PDF][PDF] Genomic Variants Associated with Resistance to High Fat Diet Induced obesity in a primate Model

KM Aagaard - academia.edu
… we have consistently observed that a 36% fat diet leads to obesity in the majority, but not all,
genomic loci rendering resistance to obesity despite chronic consumption of a high fat diet

Construction of cynomolgus monkey type 2 diabetes models by combining genetic prediction model with high-energy diet

P Li, H Ye, F Guo, J Zheng, W Shen, D Xie, S Shi… - … et Biophysica Acta (BBA …, 2025 - Elsevier
… rate of establishing T2D monkey models while decreased the … high-efficiency method to
establish T2D monkey models by combining the genetic prediction model and high-energy diet, …

123: Novel host genomic variants associated with resistance to high fat diet (HFD) induced obesity in a primate model alter their gut microbiome

R Pace, A Prince, J Ma, A Harris, K Baquero… - American Journal of …, 2017 - ajog.org
… Using our primate model, functional SNPs of interest were identified using a novel exon-capture
hybrid array targeting 783 lipid metabolism and obesity related genes. Metagenomic …

[HTML][HTML] Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition

JM Elsakr, JC Dunn, K Tennant, SK Zhao, K Kroeten… - Molecular …, 2019 - Elsevier
… macaque model of maternal high fat, calorically dense diet to … obesity and glucose tolerance
varied within the same diet … These genomic variants that affect maternal GAUC may have …

124: Genomic variants associated with resistance to high fat diet induced obesity in a primate model

RM Pace, RA Harris, CE Alcott, EL Sullivan… - American Journal of …, 2017 - ajog.org
… a 36% fat diet leads to obesity in the majority, … genomic loci to traits of adult maternal obesity
resistance, relative weight stability, and insulin sensitivity following prolonged high fat diet

[HTML][HTML] Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome

KM Aagaard-Tillery, K Grove, J Bishop… - Journal of molecular …, 2008 - ncbi.nlm.nih.gov
genomes in an effort to produce high-resolution genome-wide … (Bishop et al. 2008), alongside
murine models of obesity (… -term high-fat intake-induced obesity murine models, others …

Maternal Western-style diet in nonhuman primates leads to offspring islet adaptations including altered gene expression and insulin hypersecretion

DT Carroll, JM Elsakr, A Miller, J Fuhr… - … Endocrinology and …, 2023 - journals.physiology.org
… in response to maternal obesity and high-fat diet feeding has been associated with increased
… is associated with adverse clinical outcomes of insulin resistance, including increased fat

Nonhuman primates and translational research—cardiovascular disease

LA Cox, M Olivier, K Spradling-Reeves… - ILAR …, 2017 - academic.oup.com
genetic loci and genetic variation that are correlated with CVD risk have been conducted with
the pedigreed baboon colony at the Southwest National Primate … insulin resistance, obesity

[HTML][HTML] Genetic regulatory effects in response to a high-cholesterol, high-fat diet in baboons

W Lin, JD Wall, G Li, D Newman, Y Yang, M Abney… - Cell Genomics, 2024 - cell.com
… In contrast, non-human primates share a striking genetic and physiological resemblance
to … genetic resources have made baboons one of the preferred primate models for genetic