Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease. Due to
its long clinical course and lack of an effective treatment, AD has become a major public
health problem in the USA and worldwide. Due to variation in age-at-onset, AD is classified
into early-onset (< 60 years) and late-onset (≥ 60 years) forms with early-onset accounting
for only 5–10% of all cases. With the exception of a small number of early-onset cases that
are afflicted because of high penetrant single gene mutations in APP, PSEN1, and PSEN2 …