Ghrelin signaling in the ventral hippocampus stimulates learned and motivational aspects of feeding via PI3K-Akt signaling
BACKGROUND: The stomach-derived hormone ghrelin drives higher-order feeding
processes related to food reward and food seeking via central nervous system signaling at
its receptor (GHSR1A). The specific nuclei mediating these effects are only partially
understood. Here, we use a rat model to examine whether ghrelin signaling in the ventral
subregion of the hippocampus (VHPC), a brain substrate of recent interest in energy
balance control, affects learned and motivational aspects of feeding behavior. METHODS …
processes related to food reward and food seeking via central nervous system signaling at
its receptor (GHSR1A). The specific nuclei mediating these effects are only partially
understood. Here, we use a rat model to examine whether ghrelin signaling in the ventral
subregion of the hippocampus (VHPC), a brain substrate of recent interest in energy
balance control, affects learned and motivational aspects of feeding behavior. METHODS …
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