Global transcriptome analysis in influenza-infected mouse lungs reveals the kinetics of innate and adaptive host immune responses
C Pommerenke, E Wilk, B Srivastava, A Schulze… - PloS one, 2012 - journals.plos.org
An infection represents a highly dynamic process involving complex biological responses of
the host at many levels. To describe such processes at a global level, we recorded gene
expression changes in mouse lungs after a non-lethal infection with influenza A virus over a
period of 60 days. Global analysis of the large data set identified distinct phases of the host
response. The increase in interferon genes and up-regulation of a defined NK-specific gene
set revealed the initiation of the early innate immune response phase. Subsequently …
the host at many levels. To describe such processes at a global level, we recorded gene
expression changes in mouse lungs after a non-lethal infection with influenza A virus over a
period of 60 days. Global analysis of the large data set identified distinct phases of the host
response. The increase in interferon genes and up-regulation of a defined NK-specific gene
set revealed the initiation of the early innate immune response phase. Subsequently …
[PDF][PDF] Global Transcriptome Analysis in Influenza-Infected Mouse Lungs Reveals the
C Pommerenke, E Wilk, B Srivastava, A Schulze… - 2012 - pdfs.semanticscholar.org
An infection represents a highly dynamic process involving complex biological responses of
the host at many levels. To describe such processes at a global level, we recorded gene
expression changes in mouse lungs after a non-lethal infection with influenza A virus over a
period of 60 days. Global analysis of the large data set identified distinct phases of the host
response. The increase in interferon genes and up-regulation of a defined NK-specific gene
set revealed the initiation of the early innate immune response phase. Subsequently …
the host at many levels. To describe such processes at a global level, we recorded gene
expression changes in mouse lungs after a non-lethal infection with influenza A virus over a
period of 60 days. Global analysis of the large data set identified distinct phases of the host
response. The increase in interferon genes and up-regulation of a defined NK-specific gene
set revealed the initiation of the early innate immune response phase. Subsequently …
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