Background and Aims Glutathione peroxidase 3 (GPx3) plays a main role in removing hydro-
and lipoperoxides from the body. Changes in concentration and several single-nucleotide
polymorphisms (SNP) at the GPX3 gene have been associated with vascular diseases, but
the relationship of GPx3 with metabolic syndrome (MetS) remains unexplored. We
undertook this study to determine the association of GPx3 serum levels and several GPX3
SNPs with the presence of MetS in Mexican subjects. Methods Clinical, biochemical, and …

Methods. Clinical, biochemical, and anthropometric evaluation were conducted in 426
subjects assigned to three groups: control (n 5 42); risk group (RG, n 5 200), and MetS group
(n 5 184). Insulin sensitivity (IS) and cardiovascular risk were determined by the QUICKI and
TG/HDL-C index, respectively. Serum GPx3 was determined by enzyme immunoassay and
polymorphisms within GPX3 gene were identified by nucleotide sequencing. Results. MetS
group showed low IS and increased cardiovascular risk with respect to controls as well as …