Glycerol-3-phosphate acyltransferase isoform-4 (GPAT4) limits oxidation of exogenous fatty acids in brown adipocytes
DE Cooper, TJ Grevengoed, EL Klett… - Journal of Biological …, 2015 - ASBMB
Glycerol-3-phosphate acyltransferase-4 (GPAT4) null pups grew poorly during the suckling
period and, as adults, were protected from high fat diet-induced obesity. To determine why
Gpat4−/− mice failed to gain weight during these two periods of high fat feeding, we
examined energy metabolism. Compared with controls, the metabolic rate of Gpat4−/− mice
fed a 45% fat diet was 12% higher. Core body temperature was 1 ºC higher after high fat
feeding. Food intake, fat absorption, and activity were similar in both genotypes. Impaired …
period and, as adults, were protected from high fat diet-induced obesity. To determine why
Gpat4−/− mice failed to gain weight during these two periods of high fat feeding, we
examined energy metabolism. Compared with controls, the metabolic rate of Gpat4−/− mice
fed a 45% fat diet was 12% higher. Core body temperature was 1 ºC higher after high fat
feeding. Food intake, fat absorption, and activity were similar in both genotypes. Impaired …
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