Enzymes from pathogens often modulate host protein post-translational modifications
(PTMs), facilitating survival and proliferation of pathogens. Shigella virulence factors IpaJ
and IcsB induce proteolytic cleavage and lysine fatty acylation on host proteins, which cause
Golgi stress and suppress innate immunity, respectively. However, it is unknown whether
host enzymes could reverse such modifications introduced by pathogens' virulence factors
to suppress pathogenesis. Herein, we report that SIRT2, a potent lysine defatty-acylase, is …