A set of coordinated interactions between gut microbiota and the immune cells surveilling
the intestine play a key role in shaping local immune responses and intestinal health.
Gpr109a is a G protein–coupled receptor expressed at a very high level on innate immune
cells and previously shown to play a key role in the induction of colonic regulatory T cells. In
this study, we show that Gpr109a−/− Rag1−/− mice exhibit spontaneous rectal prolapse and
colonic inflammation, characterized by the presence of an elevated number of IL-17 …

A set of coordinated interactions between gut microbiota and the immune cells surveilling
the intestine play a key role in shaping local immune responses and intestinal health. There
are several immunoregulatory mechanisms in place that prevent the needless activation of
immune cells against harmless gut bacteria. The dysregulation of interleukin-23 (IL-23)
plays a critical role in the induction of several inflammatory diseases including inflammatory
bowel disease (IBD). However, the molecular mechanisms regulating IL-23 production are …