Group V phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group IVA phospholipase A2
YJ Kim, KP Kim, SK Han, NM Munoz, X Zhu… - Journal of Biological …, 2002 - ASBMB
We reported previously that exogenously added human group V phospholipase A 2 (hVPLA
2) could elicit leukotriene B 4 (LTB 4) biosynthesis in human neutrophils (Han, SK, Kim, KP,
Koduri, R., Bittova, L., Munoz, NM, Leff, AR, Wilton, DC, Gelb, MH, and Cho, W.(1999) J. Biol.
Chem. 274, 11881–11888). To determine the mechanism of the hVPLA 2-induced LTB 4
biosynthesis in neutrophils, we thoroughly examined the effects of hVPLA 2 and their lipid
products on the activity of group IVA cytosolic PLA 2 (cPLA 2) and LTB 4 biosynthesis under …
2) could elicit leukotriene B 4 (LTB 4) biosynthesis in human neutrophils (Han, SK, Kim, KP,
Koduri, R., Bittova, L., Munoz, NM, Leff, AR, Wilton, DC, Gelb, MH, and Cho, W.(1999) J. Biol.
Chem. 274, 11881–11888). To determine the mechanism of the hVPLA 2-induced LTB 4
biosynthesis in neutrophils, we thoroughly examined the effects of hVPLA 2 and their lipid
products on the activity of group IVA cytosolic PLA 2 (cPLA 2) and LTB 4 biosynthesis under …