Hürthle cell neoplasms of the thyroid: Pathologic outcomes and ultrasonographic analysis
TJ Shin, CC Rabbani, HD Murthy… - Laryngoscope …, 2020 - Wiley Online Library
TJ Shin, CC Rabbani, HD Murthy, K Traylor, MW Sim
Laryngoscope Investigative Otolaryngology, 2020•Wiley Online LibraryBackground Fine‐needle aspiration (FNA) of thyroid nodules suspicious for Hürthle cell
neoplasms (HCN) have uncertain rate of malignancy. We aim to characterize rate and
predictors of malignancy at our institution and compare these findings with established
literature to help guide management. Methods Single tertiary‐referral center, retrospective
study of 166 adults who underwent hemithyroidectomy or total thyroidectomy following FNA
suspicious for HCN from 1998‐2018. Demographic information and surgical histopathologic …
neoplasms (HCN) have uncertain rate of malignancy. We aim to characterize rate and
predictors of malignancy at our institution and compare these findings with established
literature to help guide management. Methods Single tertiary‐referral center, retrospective
study of 166 adults who underwent hemithyroidectomy or total thyroidectomy following FNA
suspicious for HCN from 1998‐2018. Demographic information and surgical histopathologic …
Background
Fine‐needle aspiration (FNA) of thyroid nodules suspicious for Hürthle cell neoplasms (HCN) have uncertain rate of malignancy. We aim to characterize rate and predictors of malignancy at our institution and compare these findings with established literature to help guide management.
Methods
Single tertiary‐referral center, retrospective study of 166 adults who underwent hemithyroidectomy or total thyroidectomy following FNA suspicious for HCN from 1998‐2018. Demographic information and surgical histopathologic results were collected. Preoperative ultrasonography was independently scored on the American College of Radiology Thyroid Imaging Reporting and Data System (TI‐RADS) by a board‐certified head and neck radiologist.
Results
There were 39 males and 127 females. Overall, 25 (15.1%) patients had carcinoma, with 15 (9%) being Hürthle cell carcinoma (HCC). Men had higher incidence of carcinoma (25.6% v. 11.8%, P = .035), and especially older males. Contralateral carcinoma was seen in 3 of 13 (23.1%) patients that underwent completion thyroidectomy. Patients with carcinoma had larger nodules (average diameter 3.3 cm versus 2.5 cm, respectively, P = .01), but no association with TI‐RADS.
Conclusion
Adults with nodules suspicious for HCN have significant risk of malignancy consistent with prior studies. Older males and larger nodule diameter are associated with malignancy in this cohort, but TI‐RADS grade is not. These findings provide a framework for management and counseling for lesions suspicious for HCN.
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