… In summary, our in vitro study suggests that BRAF/MEK inhibitor-induced redifferentiation
effect in PTC cells harboring BRAF V600E can be promoted by HER inhibitor via effectively …

… In conclusion, MAPK inhibitors enhance HDACi-induced redifferentiation in PTC cells harboring
… HER inhibitor promotes BRAF/MEK inhibitor-induced redifferentiation in papillary thyroid …

… redifferentiation studies that used MAPK pathway inhibitors … pathway inhibitors to evaluate
their capacity to redifferentiate … lung, 1 of 15 with BRAF/MEK inhibitor–refractory BRAF V600E …

… thyroid cancer cell lines. We tested their effects on cell growth and as redifferentiation …
cancer patients with disease progression during BRAF or BRAF/MEK inhibitor treatment and …

… The Her kinase inhibitor lapatinib prevented MAPK rebound and overcame BRAF-mutated …
Selective VCP inhibitors promoted RAI uptake in these same models as well as in primary …

… MEK inhibition for 18 months with improvement in her tumor … to tumor redifferentiation that
can be seen with BRAF inhibitor … inhibition in thyroid cancer and combination BRAF and MEK …

… also upregulate the expression of tumor-promoting genes (eg, vascular endothelial
growth … therapy of BRAF/MEK inhibitors (dabrafenib/selumetinib) with an HER inhibitor (lapatinib) …

… in thyroid cancer tumorigenesis (Figure 1). The inhibition of mTOR promotes redifferentiation
of thyroid … Use of a HER inhibitor in combination with a BRAF/MEK inhibitor increased …

… .2, 4 Therefore, strategies for redifferentiating PTC cells to increase NIS levels may be …
chosen because of their recent approval for use in anaplastic thyroid cancer and their efficacy in …

… transcription factors to promoting expression of HER3 [69]. The reactivation of … of HER
inhibitor to BRAF/MEK inhibitor overcomes resistance to vemurafenib in BRAF mutated thyroid …