… diabetic wounds in mice. Here, we present additional data demonstrating that HIF-1α activity,
… We demonstrate that high glucose-induced impairments in HIF-1α transactivation persist …

… Although the detailed molecular mechanisms underlying impairment of HIF-1α in diabetes
or in high glucose remain poorly understood, some recent studies envision this inhibition …

… HIF-1α in OSA in relation to the possible pathways in which they contribute to metabolic
disorders. … To assess the influence of HIF-1α on the progression of obesity-induced diabetes in …

… diabetic kidney is submaximal relative to the degree of hypoxia. Although absolute HIF-1α
levels in diabetic … beta cell dysfunction that can be reversed by deletion of HIF-1α. Moreover, …

… to the changes in HIF-1α transactivation and HIF-1α protein … with an increased risk of diabetic
embryopathy, adverse long-… Hif1a insufficiency display increased susceptibility to diabetic …

… improve diabetes or its complications via regulation of HIF-1α … HIF-1α seen in diabetes (35).
Insulin deficiency associated with β cell dysfunction or death would further decrease HIF-1α …

… functional role of HIF-1α in the development of diabetic cardiomyopathy. We … HIF-1α may
compromise cardiac responses under diabetic conditions and increase susceptibility to diabetic …

… HIF-1α, IL-6 and TNF-α signalling pathway for dysfunction and … Thus, in the light of the key
role of HIF-1α in regulating … of HIF-1α in the retinal tissues of non-diabetic rats and diabetic rats …

… We also provided mechanistic insights that HIF-1α is repressed in the medulla of diabetic
mice despite hypoxia and that Pro582Ser polymorphism confers less sensitivity to the inhibitory …

… This study demonstrated that HIF-1α improved mitochondrial dysfunction and restricted
mitochondria-dependent apoptosis in tubular cells of DN via the HO-1 pathway (Figure 6). This …