[HTML][HTML] HLA-DR/DQ molecular mismatch: a prognostic biomarker for primary alloimmunity
C Wiebe, V Kosmoliaptsis, D Pochinco… - American journal of …, 2019 - Elsevier
Alloimmune risk stratification in renal transplantation has lacked the necessary prognostic
biomarkers to personalize recipient care or optimize clinical trials. HLA molecular mismatch
improves precision compared to traditional antigen mismatch but has not been studied in
detail at the individual molecule level. This study evaluated 664 renal transplant recipients
and correlated HLA-DR/DQ single molecule eplet mismatch with serologic, histologic, and
clinical outcomes. Compared to traditional HLA-DR/DQ whole antigen mismatch, HLA …
biomarkers to personalize recipient care or optimize clinical trials. HLA molecular mismatch
improves precision compared to traditional antigen mismatch but has not been studied in
detail at the individual molecule level. This study evaluated 664 renal transplant recipients
and correlated HLA-DR/DQ single molecule eplet mismatch with serologic, histologic, and
clinical outcomes. Compared to traditional HLA-DR/DQ whole antigen mismatch, HLA …