… HOXB7 as an ER cofactor in the activation of ER target genes and HER2. Furthermore, we
have … the upstream regulators of HOXB7 that are amenable to therapeutic targeting directed at …

… in activated ER-mediated tamoxifen resistance. In a recent manuscript Jin et al. [8] … HOXB7
acts as an ERα cofactor thereby enhancing the expression of ER-target genes including HER2…

… regions of its target genes, along with cofactors such PBX1, … We showed that HOXB7
overexpression renders breast … of key ER target genes such as CA12, MYC and HER2. What is …

… generally lead to ligand-independent constitutive activation of … HOXB7 and ERBB2–EGFR
expression and activation. The … increased HOXB7 and transcriptional cofactor binding at an …

… activated by HOXB7, because SMAD3 phosphorylation seems to be higher in primary BC
from Hoxb7/Her2 double-transgenic mice than from Her2/… regulation of several genes [28] and …

… Then we characterized HOXB7 and its putative downstream … of HOX proteins target genes,
these cofactors also have an … ERα target genes, including HER2, via MYC pathway 110. …

… its lack of hormone and HER2 receptor expression and exist as … ER stress which causes
calcium influx and calpain activation … leg and keeping me at the top of my game with intellectual …

… activated by HOXB7, because SMAD3 phosphorylation seems to be higher in primary BC
from Hoxb7/Her2 double-transgenic mice than from Her2/… regulation of several genes [28] and …

… oncogene B2 (ErbB2, also named HER2/NEU) have been used … These cofactors interact
directly or indirectly with ER and may … One of them HOXB7 was shown to be an ERα-responsive …

… widely re-expressed in cancer [7] and capable of activating several oncogenic pathways [8]. …
HOXB7–ERα complex enhances transcription of many ERα target genes, including HER2 […