Protein quality control (PQC) degrons are short protein segments that target misfolded
proteins for proteasomal degradation, and thus protect cells against the accumulation of
potentially toxic non-native proteins. Studies have shown that PQC degrons are hydrophobic
and rarely contain negatively charged residues, features which are shared with chaperone-
binding regions. Here we explore the notion that chaperone-binding regions may function as
PQC degrons. When directly tested, we found that a canonical Hsp70-binding motif (the …

Protein quality control (PQC) degrons are short protein segments that target misfolded
proteins for proteasomal degradation, and thus protect cells against the accumulation of
potentially toxic non-native proteins. Recent studies have shown that PQC degrons are
hydrophobic and rarely contain negatively charged residues, features which are shared with
chaperone-binding regions. Here we explore the notion that chaperone-binding regions
may function as PQC degrons. When directly tested, we found that a canonical Hsp70 …