While the broad field of ergonomics and human factors provides a strong potential in systems analysis, design and improvement, the focus risks being perceived unclear for different stakeholders. This paper addresses how focusing the interactions between Humans, Technology and Organization by using the HTO-concept contributes to the understanding, communication and use of systems thinking inherent in the discipline of Ergonomics and Human Factors. The authors’ experiences illustrate how the use of the HTO concept in various industries and in academic teaching gives advantages regarding interactions, communicativeness, attractiveness, activity and pedagogical benefits.